Because long-term opioid use often begins with treatment of acute pain (1), in March 2016, the CDC Guideline for Prescribing Opioids for Chronic Pain included recommendations for the duration of opioid therapy for acute pain and the type of opioid to select when therapy is initiated (2). However, data quantifying the transition from acute to chronic opioid use are lacking. Patient records from the IMS Lifelink+ database were analyzed to characterize the first episode of opioid use among commercially insured, opioid-naïve, cancer-free adults and quantify the increase in probability of long-term use of opioids with each additional day supplied, day of therapy, or incremental increase in cumulative dose. The largest increments in probability of continued use were observed after the fifth and thirty-first days on therapy; the second prescription; 700 morphine milligram equivalents cumulative dose; and first prescriptions with 10- and 30-day supplies. By providing quantitative evidence on risk for long-term use based on initial prescribing characteristics, these findings might inform opioid prescribing practices.
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Crunchyroll does state that free users can view episodes in 1080p on its new player FAQ page, but otherwise the feature doesn't appear to be advertised on the streaming website. Anime News Network was able to confirm that 1080p video is available in the U.K., U.S., and Sweden for free. Please note that video quality can vary by series and episode based on availability.
While HD video is free on Crunchyroll, viewers won't be able to get away from advertisements without dropping cash on a subscription. Access to same-day simulcast episodes is also limited to premium users; free users will need to wait a week to catch-up.
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